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KMID : 0545120070170081403
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 8 p.1403 ~ p.1406
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Isolation and Structure Determination of Streptochlorin, an Antiproliferative Agent from a Marine-derived Streptomyces sp. 04DH110
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Shin Hee-Jae
Jeong Hyun-Sun
Lee Hyi-Seung
Park Song-Kyu
Kim Hwan-Mook
Kwon Ho-Jeong
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Abstract
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An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.
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KEYWORD
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Streptomyces sp, 04DH110, antiproliferative agent, streptochlorin
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